Description

5'-o-Phosphorylguanylyl-(3'-5')-Guanosine is a defined dinucleotide monophosphate, a crucial building block in RNA research and synthesis. This high-purity biochemical is essential for studying RNA structure, function, and enzymatic processes, offering researchers a reliable and well-characterized standard. It is primarily utilized by biotechnology companies, academic research institutions, and pharmaceutical R&D departments focused on nucleic acid chemistry, molecular biology, and therapeutic oligonucleotide development.

Application

• Oligonucleotide Synthesis: Serves as a key phosphodiester-linked intermediate or reference standard in the chemical and enzymatic synthesis of RNA sequences.
• Biochemical Research: Used as a substrate or model compound for studying ribonuclease activity, RNA ligation mechanisms, and other nucleic acid-metabolizing enzymes.
• Molecular Biology Tools: Acts as a component in the development of probes, primers, and other tools for RNA detection and analysis.
• Pharmaceutical R&D: Employed in early-stage research for RNA-based therapeutics, including aptamer and siRNA discovery platforms.
• Analytical Standard: Functions as a high-purity chromatographic (HPLC, LC-MS) standard for the qualification and quantification of oligonucleotides.
• Enzyme Kinetics Studies: Provides a defined dinucleotide substrate for investigating the kinetics and specificity of polymerases and nucleases.

Basic Information

Product Name	5'-o-Phosphorylguanylyl-(3'-5')-Guanosine
CAS No.	33008-99-0
Molecular Formula	C20H26N10O17P2
Molecular Weight	764.42 g/mol
Synonyms	GpG; Guanylyl-(3'→5')-guanosine 5'-monophosphate; 5'-Guanylyl-guanosine; P1-(5'-Guanosyl)-P2-(5'-guanosyl) diphosphate; G(5')pp(5')G; Guanosine 5'-monophosphoryl-(3'→5')-guanosine; 5'-O-Phosphonatoguanylyl-(3'→5')-guanosine; Dinucleoside monophosphate GpG
EINECS	Contact for details

Quality Control

Every batch of our 5'-o-Phosphorylguanylyl-(3'-5')-Guanosine is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay purity and impurity profiles as determined by HPLC and spectroscopic methods. Our quality commitment supports research requiring reliable and traceable biochemical standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.