Description

[2S-(2Alpha,5Alpha,6Beta)]-6-[[(Hexahydro-1H-Azepin-1-Yl)Methylene]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Monohydrochloride is a high-purity, semi-synthetic chemical intermediate derived from the 6-APA nucleus, primarily used in advanced pharmaceutical synthesis. Its core value lies in its role as a key precursor for developing novel β-lactam antibiotics and other potent therapeutic agents. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating next-generation antimicrobials and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel cephalosporin and penicillin antibiotic derivatives.
• Antibiotic Research & Development: Serves as a key starting material for medicinal chemists developing new β-lactam structures with enhanced activity against resistant bacterial strains.
• Fine Chemical Synthesis: Used in the preparation of complex, high-value molecules for biological testing and structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production scale-up of advanced antibiotic APIs under controlled GMP environments.
• Biochemical Research: Utilized in studies investigating the mechanism of action and resistance profiles of β-lactam antibiotics.

Basic Information

Product Name	[2S-(2Alpha,5Alpha,6Beta)]-6-[[(Hexahydro-1H-Azepin-1-Yl)Methylene]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Monohydrochloride
CAS No.	32887-08-4
Molecular Formula	C16H26ClN3O3S
Molecular Weight	375.91 g/mol
Synonyms	6-[(Hexahydro-1H-azepin-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrochloride; 6-APA Azepinylmethylene Derivative Hydrochloride; (2S,5R,6R)-6-[(Hexahydro-1H-azepin-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid hydrochloride; 6-[(Hexahydroazepin-1-ylmethylene)amino]penicillanic acid hydrochloride; Azepinylmethyleneamino Penicillanic Acid HCl
EINECS	Contact for details

Quality Control

Our [2S-(2Alpha,5Alpha,6Beta)]-6-[[(Hexahydro-1H-Azepin-1-Yl)Methylene]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Monohydrochloride is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.