Description

Pivmecillinam is a prodrug ester of mecillinam, a β-lactam antibiotic belonging to the amidinopenicillin class. It is a critical pharmaceutical active ingredient valued for its specific bactericidal activity against Gram-negative bacteria, particularly in the treatment of urinary tract infections. This compound is essential for manufacturers in the pharmaceutical industry engaged in the production of specialized antibiotic formulations. Its reliable performance and specificity make it a key component in targeted antimicrobial therapy.

Application

• Pharmaceutical API: Primary use as an active pharmaceutical ingredient (API) in the manufacture of oral antibiotic medications.
• Urinary Tract Infection (UTI) Treatment: Formulated into tablets or capsules specifically indicated for the treatment of uncomplicated lower urinary tract infections caused by susceptible Gram-negative organisms like E. coli.
• Prodrug Formulations: Serves as a prodrug that is hydrolyzed in vivo to the active moiety, mecillinam, improving oral bioavailability.
• Antimicrobial Research: Used as a reference standard or intermediate in microbiological and pharmacological research focused on β-lactam antibiotics and bacterial resistance mechanisms.
• Veterinary Pharmaceuticals: Potential application in developing antibacterial treatments for veterinary use, subject to regional regulatory approvals.

Basic Information

Product Name	Pivmecillinam
CAS No.	32886-97-8
Molecular Formula	C21H33N3O5S
Molecular Weight	439.57 g/mol
Synonyms	Pivmecillinam; Pivmecillinamum; Pivmecillinam Hydrochloride (salt form); Pivampicillin analog; Amdinocillin Pivoxil; (2S,5R,6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid pivaloyloxymethyl ester; Melysin; Selexid
EINECS	Contact for details

Quality Control

Our Pivmecillinam is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. While produced to align with pharmacopeial principles, specifications can be adjusted to meet specific customer requirements. A Certificate of Analysis (COA) documenting all critical quality attributes is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.