Description

Benzyldihydrochlorothiazide is a specialized benzothiadiazine derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its precise molecular structure makes it a critical building block for developing high-potency active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is essential for R&D laboratories and production facilities focused on cardiovascular and diuretic drug development, where purity and structural integrity are paramount for efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: Primary use as a crucial synthetic precursor in the manufacture of novel thiazide diuretic and antihypertensive APIs.
• Research & Development: Serves as a key scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Chemical Synthesis: Used in organic synthesis to introduce the benzothiadiazine moiety into more complex molecular architectures.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Item	Detail
Product Name	Benzyldihydrochlorothiazide
CAS No.	32586-76-8
Molecular Formula	C15H15ClN2O4S2
Molecular Weight	410.87 g/mol
Synonyms	3-(Benzyl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; Benzyl DHCT; BDHCT; 3-Benzylchlorothiazide; Benzyl Hydrochlorothiazide Intermediate
EINECS	Contact for details

Quality Control

Our Benzyldihydrochlorothiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.