Description

Polyinosinic-Polycytidylic Acid Potassium Salt is a synthetic double-stranded RNA polymer, widely recognized as a potent immunostimulant and toll-like receptor 3 (TLR3) agonist. This compound is a critical research tool for modeling viral infections and studying innate immune responses, interferon induction, and antiviral defense mechanisms. It is essential for researchers and developers in the fields of immunology, virology, and pharmaceutical development, particularly for vaccine adjuvants and cancer immunotherapy studies.

Application

• Immunological Research: As a standard TLR3 agonist to stimulate innate immune pathways and study interferon-alpha/beta production.
• Vaccine Adjuvant Development: Investigational use in preclinical studies for enhancing the immunogenicity of vaccine candidates.
• Antiviral Studies: Used to model dsRNA viral infection and to screen for novel antiviral compounds.
• Cancer Immunotherapy Research: Employed to activate dendritic cells and macrophages, promoting an anti-tumor microenvironment.
• Cell Signaling Pathways: A key reagent for investigating PKR (Protein Kinase R) and NF-κB activation cascades.
• Biochemical Standard: Serves as a reference standard in analytical and quality control laboratories.

Basic Information

Product Name	Polyinosinic-Polycytidylic Acid Potassium Salt
CAS No.	31852-29-6
Molecular Formula	(C10H11N4O8P2 · C9H10N3O8P2)n · xK
Molecular Weight	Variable polymer (Contact for details)
Synonyms	Poly(I:C) Potassium Salt; Polyinosinic:polycytidylic acid potassium; Poly I:C K+ salt; PIC Potassium Salt; Poly rI:rC Potassium; TLR3 Agonist (Poly I:C); dsRNA Potassium Salt; Inosinic acid-cytidylic acid copolymer potassium salt
EINECS	Contact for details

Quality Control

Our Polyinosinic-Polycytidylic Acid Potassium Salt is produced under stringent conditions to ensure high purity and biological activity, suitable for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as identification, assay/polymer length, endotoxin levels, and bioburden. We adhere to cGMP guidelines for manufacturing, ensuring traceability and consistency for preclinical and investigational use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or fibrous solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Poly I:C content)
Potassium Content	As per theoretical
Endotoxin	< 10 EU/mg
Solubility	Soluble in water or buffer
Biological Activity (Cell-based assay)	Induces IFN-α in appropriate cell lines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.