Description

Lofexidine CAS NO 31036-80-3 is a selective α-2 adrenergic receptor agonist of significant pharmaceutical importance. This compound is primarily valued for its role in managing opioid withdrawal symptoms, offering a non-opioid therapeutic pathway. It is a critical active pharmaceutical ingredient (API) sought by pharmaceutical manufacturers, research institutions, and compounding facilities engaged in addiction medicine and neuropharmacology.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of prescription medications for opioid detoxification.
• Clinical research applications in studies related to autonomic nervous system regulation and substance dependence.
• Utilization in the development of combination therapies for managing withdrawal syndromes.
• Reference standard in analytical laboratories for quality control and method development (HPLC, GC, MS).
• Precursor or intermediate in advanced pharmaceutical synthesis for novel adrenergic agents.

Basic Information

Product Name	Lofexidine
CAS No.	31036-80-3
Molecular Formula	C11H12Cl2N2O
Molecular Weight	259.13 g/mol
Synonyms	2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; Lofexidine Hydrochloride (common salt form); BritLofex; Lofetensin; Loxacor; KA-13; RMI-14042A; (RS)-Lofexidine
EINECS	Contact for details

Quality Control

Our Lofexidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA), including identification, assay, and impurity profiles (tested by HPLC), is provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.