Description

10-(2-(Dimethylamino)Ethyl)-5-Methyl-5H-Dibenz(B,F)Azepine CAS NO 30490-51-8 is a high-purity, advanced pharmaceutical intermediate belonging to the dibenzazepine class of compounds. This chemical is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs) and for research into novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block in the production of tricyclic antidepressant and antipsychotic drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for the design and development of new central nervous system (CNS) targeting compounds.
• Process Development & Scale-Up: Employed in optimizing synthetic routes for the commercial manufacturing of specialty pharmaceuticals.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Applied in studies investigating neurotransmitter receptor interactions and pharmacological mechanisms.

Basic Information

Product Name	10-(2-(Dimethylamino)Ethyl)-5-Methyl-5H-Dibenz(B,F)Azepine
CAS No.	30490-51-8
Molecular Formula	C19H22N2
Molecular Weight	278.40 g/mol
Synonyms	5-Methyl-10-(2-(dimethylamino)ethyl)-5H-dibenzo[b,f]azepine; Desipramine Impurity; Desmethylimipramine; G-35020; Norimipramine; NSC 114495; 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-; 10,11-Dihydro-5-methyl-5H-dibenz[b,f]azepine
EINECS	Contact for details

Quality Control

Our 10-(2-(Dimethylamino)Ethyl)-5-Methyl-5H-Dibenz(B,F)Azepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.