Description

6-(p-Azidobenzamido)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, Monopotassium Salt is a key synthetic intermediate and a functionalized penicillin derivative, primarily recognized for its role in the development of novel β-lactam antibiotics and as a biochemical tool. Its value lies in its unique azido functional group, which enables site-specific conjugation and photoaffinity labeling in advanced research applications. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and fine chemical manufacturers focused on antibiotic discovery and proteomics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel penicillin and cephalosporin analogs with modified side chains.
• Bioconjugation & Probe Development: The azido group allows for click chemistry reactions (e.g., CuAAC) to create fluorescent or affinity tags for biological studies.
• Photoaffinity Labeling: Used to identify and study drug-protein interactions and binding sites within biological systems.
• Antibiotic Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to combat antibiotic resistance.
• Enzyme Inhibition Studies: Acts as a mechanism-based inhibitor or probe for β-lactamase and penicillin-binding proteins (PBPs).
• Chemical Biology Tool: Employed in the development of activity-based protein profiling (ABPP) reagents.

Basic Information

Item	Details
Product Name	6-(p-Azidobenzamido)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, Monopotassium Salt
CAS No.	3381-71-3
Molecular Formula	C17H16KN5O5S
Molecular Weight	441.51 g/mol
Synonyms	6-[(4-Azidobenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt; Potassium 6β-(4-azidobenzamido)penicillanate; 6-APA azido derivative potassium salt; p-Azidobenzamidopenicillanic acid potassium salt; Azidobenzoyl penicillin potassium salt; Penicillin-based photoaffinity label; 6β-(p-Azidobenzamido)penicillanic acid potassium salt
EINECS	Contact for details

Quality Control

Our 6-(p-Azidobenzamido)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, Monopotassium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.