Description

2,3,5,6-Tetrafluoro-4-Methoxybenzoic Acid is a fluorinated aromatic carboxylic acid derivative that serves as a versatile and high-value synthetic building block. Its unique structure, featuring a methoxy group and multiple fluorine atoms on the benzene ring, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require advanced fluorinated intermediates to develop novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Polymer & Material Science: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy for coatings and films.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D for constructing complex fluorinated aromatic systems and exploring structure-activity relationships.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-Methoxybenzoic Acid
CAS No.	3153-01-3
Molecular Formula	C8H4F4O3
Molecular Weight	224.11 g/mol
Synonyms	4-Methoxy-2,3,5,6-tetrafluorobenzoic Acid; 2,3,5,6-Tetrafluoro-4-methoxybenzoic acid; 2,3,5,6-Tetrafluoro-p-anisic acid; Benzoic acid, 2,3,5,6-tetrafluoro-4-methoxy-; Tetrafluoromethoxybenzoic acid; TFMBA; α,α,α,α-Tetrafluoro-4-methoxybenzoic acid
EINECS	221-600-4

Quality Control

Our 2,3,5,6-Tetrafluoro-4-Methoxybenzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.