Description

3-Fluoromandelic Acid is a versatile fluorinated aromatic compound that serves as a critical chiral building block and synthetic intermediate. Its unique structure, featuring both a carboxylic acid and a fluorine-substituted benzylic hydroxyl group, makes it invaluable for introducing fluorinated motifs into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to modulate the biological activity, metabolic stability, and physicochemical properties of their target molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Building block for developing novel herbicides and pesticides where the fluorine atom enhances lipophilicity and target binding.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis, leveraging its mandelic acid backbone for stereocontrol.
• Biochemical Research: Probe or substrate in enzymatic studies, especially for investigating the activity of hydroxymandelate synthases or decarboxylases.
• Material Science: Monomer or modifier for synthesizing specialty polymers with tailored surface properties or stability.
• Fine Chemical Synthesis: Intermediate for producing fluorinated flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	3-Fluoromandelic Acid
CAS No.	395-05-1
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	(3-Fluorophenyl)(hydroxy)acetic acid; 2-Hydroxy-2-(3-fluorophenyl)acetic acid; 3-Fluorophenylglycolic acid; DL-3-Fluoromandelic acid; (±)-3-Fluoromandelic acid; 3-Fluoro-α-hydroxybenzeneacetic acid; 3-Fluorobenzenehydroxyacetic acid; 3-Fluorophenylhydroxyethanoic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Chiral Purity (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.