Description

Methyl 2-Fluoro-4-Nitrobenzenecarboxylate is a high-purity fluorinated aromatic ester, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of the fluorine and nitro groups, which enable precise functionalization for creating complex target molecules. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Dye & Pigment Intermediate: Employed in the manufacture of specialized colorants and fluorescent markers.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Academic & Contract Research: Used in university and CRO laboratories for method development and exploring new synthetic pathways in medicinal chemistry.

Basic Information

Product Name	Methyl 2-Fluoro-4-Nitrobenzenecarboxylate
CAS No.	392-09-6
Molecular Formula	C8H6FNO4
Molecular Weight	199.14 g/mol
Synonyms	Methyl 2-Fluoro-4-nitrobenzoate; 2-Fluoro-4-nitrobenzoic Acid Methyl Ester; Benzoic acid, 2-fluoro-4-nitro-, methyl ester; Methyl 4-Nitro-2-fluorobenzoate; 4-Nitro-2-fluorobenzoic Acid Methyl Ester; 2-Fluoro-4-nitro Methyl Benzoate; Methyl o-fluoro-p-nitrobenzoate
EINECS	206-876-1

Quality Control

Our Methyl 2-Fluoro-4-Nitrobenzenecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.