Description

Methyl 3,4-Difluorobenzoate is a high-purity fluorinated aromatic ester serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzoate ring, which significantly influences the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where the difluoro motif can improve lipophilicity and target binding.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce fluorine into polymer backbones, enhancing chemical resistance and thermal stability.
• Organic Electronic Materials: Acts as a building block for electron-deficient aromatic units used in organic semiconductors and OLED materials.
• General Fluorination Chemistry: A versatile starting material for further functionalization via hydrolysis, reduction, or cross-coupling reactions to access diverse difluorinated derivatives.

Basic Information

Product Name	Methyl 3,4-Difluorobenzoate
CAS No.	369-25-5
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	3,4-Difluorobenzoic Acid Methyl Ester; Methyl 3,4-Difluorobenzoate; Benzoic acid, 3,4-difluoro-, methyl ester; 3,4-Difluorobenzoic acid methyl ester; Methyl 3,4-difluorobenzoate; 369-25-5; Methyl 3,4-difluorobenzenecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 3,4-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.