Description

α-Fluorocinnamic Acid is a versatile fluorinated aromatic building block characterized by a cinnamic acid backbone with a fluorine substituent on the alpha carbon. This structural motif is highly valuable in medicinal chemistry and materials science for introducing fluorine atoms to modulate the biological activity, metabolic stability, and physical properties of target molecules. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Research: Used in developing novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated organic semiconductors and liquid crystal compounds, improving charge transport and thermal stability.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid and alkene functionalities allow its incorporation into peptide backbones or use as a linker for bioconjugation strategies.
• Chemical Biology Probes: Utilized in the design of activity-based probes and fluorophore tags for studying enzyme mechanisms and cellular imaging.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer chains, altering surface properties, chemical resistance, and optical characteristics.

Basic Information

Product Name	α-Fluorocinnamic Acid
CAS No.	350-90-3
Molecular Formula	C9H7FO2
Molecular Weight	166.15 g/mol
Synonyms	(E)-3-Fluoro-3-phenylacrylic acid; 3-Fluoro-3-phenylpropenoic acid; 2-Fluorocinnamic acid; α-Fluorocinnamic acid; trans-α-Fluorocinnamic acid; (E)-α-Fluorocinnamic acid; 3-Fluoro-3-phenyl-2-propenoic acid; Fluorocinnamic acid
EINECS	Contact for details

Quality Control

Our α-Fluorocinnamic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.