Description

Polythiazide (200 Mg) is a high-purity active pharmaceutical ingredient (API) belonging to the thiazide class of diuretics. This compound is critical for the formulation of antihypertensive and diuretic medications, offering reliable therapeutic efficacy. It is primarily required by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and production. Our product is supplied with a guaranteed specification to ensure consistency and compliance for your critical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription antihypertensive medications.
• Diuretic Formulations: Key component in drugs used to treat edema associated with congestive heart failure, liver cirrhosis, and renal dysfunction.
• Combination Therapies: Used in fixed-dose combination drugs with other antihypertensive agents like β-blockers or ACE inhibitors.
• Clinical Research: Serves as a reference standard and raw material for pharmacokinetic, pharmacodynamic, and bioavailability studies.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded diuretic medications.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing fluid retention in animals.

Basic Information

Product Name	Polythiazide (200 Mg)
CAS No.	346-18-9
Molecular Formula	C11H13ClN3O4S3
Molecular Weight	439.90 g/mol
Synonyms	6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; P-2525; Renese; Nephril; Drenusil; Thiazide diuretic; 1,2,4-Benzothiadiazine-7-sulfonamide derivative
EINECS	206-469-6

Quality Control

Our Polythiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent purity and identity criteria, typical for pharmaceutical-grade APIs. A Certificate of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment. We support compliance with major pharmacopoeial standards (USP/EP) and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets USP <61> criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.