Description

4-Trifluoromethylsalicylic Acid is a fluorinated derivative of salicylic acid, characterized by the presence of a trifluoromethyl group at the 4-position. This structural modification imparts unique electronic and steric properties, making it a valuable advanced pharmaceutical intermediate and a versatile building block in organic synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting inflammation and central nervous system disorders.
• Agrochemical Synthesis: Used as a building block for developing new herbicides and pesticides, leveraging the bioactivity of the salicylate core enhanced by fluorine.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the development of novel polymers and advanced organic materials with specific electronic characteristics.
• Chemical Research & Development: A versatile reagent for introducing the trifluoromethylsalicylate moiety into more complex molecular architectures in medicinal and synthetic chemistry.

Basic Information

Item	Details
Product Name	4-Trifluoromethylsalicylic Acid
CAS No.	328-90-5
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	2-Hydroxy-4-(trifluoromethyl)benzoic Acid; 4-(Trifluoromethyl)salicylic Acid; α-Hydroxy-4-(trifluoromethyl)benzoic Acid; 4-TFM-SA; Salicylic Acid, 4-Trifluoromethyl-; 4-Carboxy-3-hydroxybenzotrifluoride
EINECS	206-333-4

Quality Control

Our 4-Trifluoromethylsalicylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its nature as a strong acid/organic solvent, store separately from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	168°C - 172°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.