Description

3-Nitro-5-(Trifluoromethyl)Benzoic Acid is a high-value aromatic building block characterized by its nitro and trifluoromethyl substituents. This compound is essential for synthesizing advanced pharmaceutical intermediates and agrochemicals, where its unique electronic properties can modulate biological activity and metabolic stability. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and bioavailability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals with specific electronic or optical properties.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of fluorine substitution on aromatic systems in medicinal and synthetic chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	3-Nitro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	328-80-3
Molecular Formula	C8H4F3NO4
Molecular Weight	235.12 g/mol
Synonyms	5-(Trifluoromethyl)-3-nitrobenzoic acid; 3-Nitro-5-trifluoromethylbenzoic acid; Benzoic acid, 3-nitro-5-(trifluoromethyl)-; 328-80-3; α,α,α-Trifluoro-5-nitro-m-toluic acid; 3-Nitro-α,α,α-trifluoro-m-toluic acid; m-Toluic acid, α,α,α-trifluoro-5-nitro-
EINECS	206-330-7

Quality Control

Our 3-Nitro-5-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.