Description

3-Hydroxy-5-(Trifluoromethyl)Benzoic Acid is a versatile trifluoromethylated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a carboxylic acid group with a hydroxyl group and a highly stable trifluoromethyl moiety, makes it invaluable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated compounds used in electronic displays and organic light-emitting diodes due to its influence on electronic properties.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with specific thermal, chemical, or surface properties.
• Chemical Research & Development: Employed as a standard or reagent in method development and exploratory chemistry within academic and industrial laboratories.
• Coordination Chemistry Ligand: The carboxylic acid and phenolic hydroxyl groups can act as chelating sites for metal ions, useful in catalysis and material science.

Basic Information

Product Name	3-Hydroxy-5-(Trifluoromethyl)Benzoic Acid
CAS No.	328-69-8
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	5-(Trifluoromethyl)-3-hydroxybenzoic acid; 3-Hydroxy-5-trifluoromethylbenzoic acid; Benzoic acid, 3-hydroxy-5-(trifluoromethyl)-; 3-Carboxy-5-(trifluoromethyl)phenol; 5-Trifluoromethylsalicylic acid; 3-Hydroxy-α,α,α-trifluoro-m-toluic acid; m-Hydroxy-α,α,α-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our production of 3-Hydroxy-5-(Trifluoromethyl)Benzoic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality management system is designed to meet the rigorous demands of cGMP and ISO standards for fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.