Description

3-Amino-5-(Trifluoromethyl)Benzoic Acid is a high-value aromatic building block characterized by its benzoic acid core, amino functionality, and trifluoromethyl group. This unique trifluoromethyl-substituted aniline derivative is essential for synthesizing advanced molecules where electronic and steric properties must be precisely tuned. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group enhances bioavailability and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing and aromatic properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Amino-5-(Trifluoromethyl)Benzoic Acid
CAS No.	328-68-7
Molecular Formula	C₈H₆F₃NO₂
Molecular Weight	205.14 g/mol
Synonyms	5-(Trifluoromethyl)anthranilic Acid; 3-Amino-5-trifluoromethylbenzoic Acid; Benzoic acid, 3-amino-5-(trifluoromethyl)-; 5-Amino-3-(trifluoromethyl)benzoic Acid; 3-Carboxy-5-aminobenzotrifluoride; 3-Amino-α,α,α-trifluoro-m-toluic Acid; 328-68-7; 3-Amino-5-trifluoromethyl-benzoic acid
EINECS	206-327-6

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for 3-Amino-5-(Trifluoromethyl)Benzoic Acid typically meets a purity specification of ≥97% (HPLC), with options for higher grades (≥98%, ≥99%) available. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to support cGMP and ISO standards for reliable integration into regulated synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	210°C - 215°C
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.