Description

4-Fluoroisophthalic Acid is a high-purity aromatic dicarboxylic acid derivative, distinguished by the strategic fluorine substitution on the benzene ring. This compound is a critical pharmaceutical intermediate and advanced material precursor, valued for its ability to impart unique electronic and steric properties to target molecules. It is essential for manufacturers in the life sciences, agrochemical, and specialty polymer industries seeking to develop novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting metabolic and central nervous system disorders.
• Liquid Crystal & OLED Material Synthesis: Serves as a core monomer for producing high-performance polyesters and polyamides used in display technologies and organic light-emitting diodes.
• Agrochemical Active Ingredient Precursor: Used in the manufacture of advanced herbicides and pesticides, where the fluorine atom enhances bioactivity and environmental stability.
• Metal-Organic Framework (MOF) Construction: Acts as a versatile organic linker for creating porous coordination polymers with applications in gas storage, separation, and catalysis.
• Specialty Polymer Modifier: Incorporated into engineering plastics to improve thermal stability, chemical resistance, and mechanical properties.
• Cross-coupling Reaction Substrate: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing complex fluorinated biaryl structures in medicinal chemistry.

Basic Information

Product Name	4-Fluoroisophthalic Acid
CAS No.	327-95-7
Molecular Formula	C8H5FO4
Molecular Weight	184.12 g/mol
Synonyms	4-Fluorobenzene-1,3-dicarboxylic Acid; Isophthalic Acid, 4-Fluoro-; 1,3-Benzenedicarboxylic Acid, 4-Fluoro-; 4-Fluoro-1,3-benzenedicarboxylic Acid; 4-Fluoroisophthalicacid; 4-Fluoroisophthalate; 4-Fluorophthalic Acid (common misnomer); 4-F-IPA
EINECS	206-326-5

Quality Control

Our 4-Fluoroisophthalic Acid is manufactured under a cGMP-compliant quality management system (ISO 9001 certified) to ensure batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical testing, including HPLC for purity, Karl Fischer titration for moisture, and residual solvent analysis by GC. A detailed Certificate of Analysis (COA) confirming identity, purity, and specification compliance is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent product degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.