Description

2-Amino-6-(Trifluoromethyl)Benzoic Acid is a high-value trifluoromethylated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a carboxylic acid functional group adjacent to a trifluoromethyl moiety, makes it indispensable for creating compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought after by pharmaceutical, agrochemical, and specialty chemical R&D sectors for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for constructing chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into the design of specialty polymers, liquid crystals, and organic electronic materials to modify solubility and electronic properties.
• Fluorine Chemistry Research: An essential compound for studying structure-activity relationships (SAR) in medicinal chemistry and the effects of fluorine substitution.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	2-Amino-6-(Trifluoromethyl)Benzoic Acid
CAS No.	314-46-5
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	6-(Trifluoromethyl)anthranilic Acid; 2-Amino-α,α,α-trifluoro-o-toluic Acid; 2-Amino-6-trifluoromethylbenzoic Acid; Benzoic acid, 2-amino-6-(trifluoromethyl)-; 6-Trifluoromethylanthranilic Acid; o-Amino-α,α,α-trifluorotoluic Acid; 2-Carboxy-3-aminobenzotrifluoride
EINECS	206-250-4

Quality Control

Our 2-Amino-6-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.