Description

2-(Trifluoromethyl)Benzoyl Fluoride is a versatile and highly reactive fluorinated aromatic building block. This compound is valued for its ability to introduce the trifluoromethylbenzoyl moiety into complex molecular architectures, significantly altering physicochemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Specialty Chemicals: Employed in the modification of polymers and the creation of specialty surfactants or coatings with unique surface properties.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds in complex molecule assembly.
• Fluorination Reagent: Functions as a source of the benzoyl fluoride group in nucleophilic substitution reactions for introducing fluorinated carbonyl functionalities.

Basic Information

Product Name	2-(Trifluoromethyl)Benzoyl Fluoride
CAS No.	312-96-9
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	α,α,α-Trifluoro-o-toluoyl Fluoride; 2-(Trifluoromethyl)benzoyl fluoride; o-(Trifluoromethyl)benzoyl fluoride; Benzoyl fluoride, 2-(trifluoromethyl)-; 2-Trifluoromethylbenzoyl fluoride; 2-Carboxybenzotrifluoride fluoride; o-Trifluoromethylbenzoyl fluoride
EINECS	206-227-6

Quality Control

Our 2-(Trifluoromethyl)Benzoyl Fluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.