Description

D,L Carbidopa is a synthetic amino acid derivative and a potent peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. This compound is of significant commercial and research interest due to its role in enhancing the bioavailability and efficacy of L-DOPA, a primary treatment for Parkinson's disease. It is a critical intermediate and reference standard in the pharmaceutical industry for the development and quality control of neurological therapeutics. Global procurement teams and R&D departments in fine chemical and active pharmaceutical ingredient (API) manufacturing require a reliable, high-purity supply of this material.

Application

• Pharmaceutical Intermediate: A key raw material in the synthesis of Carbidopa API, used in combination drugs for Parkinson's disease (e.g., with Levodopa).
• Biochemical Research: Used as a reference standard and inhibitor in enzymatic studies to investigate dopamine metabolism and the function of aromatic L-amino acid decarboxylase.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and NMR analysis in quality control laboratories.
• Metabolite Studies: Employed in preclinical and clinical research to study the pharmacokinetics and peripheral effects of dopaminergic therapies.
• Process Development: Utilized in process chemistry for optimizing synthetic routes and scaling up production of related decarboxylase inhibitors.

Basic Information

Product Name	D,L Carbidopa
CAS No.	302-53-4
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	(±)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid; Lodosyn (brand name reference); MK-486; NSC-112682; Carbidopa Racemate; DL-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid; (RS)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropanoic acid
EINECS	206-123-0

Quality Control

Our D,L Carbidopa is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets exacting standards for pharmaceutical research and development. Each batch is tested for identity, purity, and impurities using validated methods such as HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. While not intended for direct human use as furnished, it is produced with traceability and consistency suitable for GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.