Description

Cgamp Disodium CAS NO 2407516-83-8 is a high-purity cyclic dinucleotide compound, specifically the disodium salt of cyclic GMP-AMP, serving as a critical second messenger in innate immune signaling pathways. Its primary value lies in its potent and specific activation of the STING (Stimulator of Interferon Genes) receptor, making it an indispensable research tool and a promising candidate for therapeutic development. This product is essential for researchers and developers in the fields of immunology, oncology, and vaccine adjuvants, where precise control of the cGAS-STING pathway is required.

Application

• Immunology Research: Fundamental studies on the cGAS-STING signaling pathway, innate immune response activation, and interferon production.
• Oncology Research: Investigation of STING agonists for cancer immunotherapy, including in vitro and in vivo model studies to stimulate anti-tumor immune responses.
• Vaccine Adjuvant Development: Used as a potent adjuvant in preclinical research to enhance the efficacy of vaccines by promoting a robust cellular immune response.
• Inflammatory Disease Models: Applied in research models for autoimmune and inflammatory diseases to understand STING pathway dysregulation.
• Drug Discovery & Screening: Serves as a reference standard and active agent in high-throughput screening assays for novel STING pathway modulators.
• Cell Signaling Studies: Used to induce specific downstream signaling events in various immune and non-immune cell types.

Basic Information

Product Name	Cgamp Disodium
CAS No.	2407516-83-8
Molecular Formula	C20H22N10Na2O14P2
Molecular Weight	774.36 g/mol
Synonyms	2'3'-cGAMP disodium salt; Cyclic [G(2',5')pA(3',5')p] disodium salt; cGAMP (2'3') disodium; Cyclic GMP-AMP disodium salt; STING agonist cGAMP disodium; c[G(2',5')pA(3',5')p] disodium; Cyclic dinucleotide disodium salt; 2',3'-cGAMP Na2
EINECS	Contact for details

Quality Control

Our Cgamp Disodium is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Endotoxin	< 0.1 EU/µg
Biological Activity (Cell-based assay)	EC50 < 1 µM in STING reporter cells

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.