Description

4-(3-Thienyl)-3-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional aromatic building block that combines a benzoic acid core with thiophene and trifluoromethyl substituents. This unique structure makes it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), offering significant advantages in tuning molecular properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced bioactivity and material characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly for molecules targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Research: Acts as a precursor for organic electronic materials, such as semiconductors for OLEDs or OFETs, due to the electron-rich thiophene and electron-withdrawing trifluoromethyl group.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis or metal-organic frameworks (MOFs), leveraging its carboxylic acid functionality for coordination.
• Fluorine Chemistry Building Block: The presence of the CF3 group makes it a valuable reagent for introducing fluorine atoms into target molecules to alter their physicochemical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for bespoke chemical synthesis projects requiring high-purity, complex aromatic intermediates.

Basic Information

Product Name	4-(3-Thienyl)-3-(Trifluoromethyl)Benzoic Acid
CAS No.	2340293-28-7
Molecular Formula	C12H7F3O2S
Molecular Weight	272.24 g/mol
Synonyms	3-(Trifluoromethyl)-4-(3-thienyl)benzoic acid; 4-(Thiophen-3-yl)-3-(trifluoromethyl)benzoic acid; Benzoic acid, 4-(3-thienyl)-3-(trifluoromethyl)-; 4-(3-Thienyl)-α,α,α-trifluoro-m-toluic acid; [1,1'-Biphenyl]-4-carboxylic acid, 3'-(trifluoromethyl)-4-(3-thienyl)- (related); TFB-TA (abbreviation); 3-CF3-4-Thienylbenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(3-Thienyl)-3-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.