Description

S-Silodosin is the pharmacologically active enantiomer of the selective α-1A adrenergic receptor antagonist silodosin. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of targeted urological therapeutics. It is primarily utilized by pharmaceutical companies and research institutions engaged in the production of medications for benign prostatic hyperplasia (BPH). Our supply ensures consistent quality and reliable availability for global pharmaceutical manufacturing and advanced research applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in finished dosage forms for the treatment of Benign Prostatic Hyperplasia (BPH).
• Key intermediate in the synthesis and scale-up of enantiomerically pure silodosin-based pharmaceuticals.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research for studying α-1A adrenergic receptor mechanisms and urological pharmacology.
• Development of novel drug delivery systems and combination therapies targeting lower urinary tract symptoms.

Basic Information

Product Name	S-Silodosin
CAS No.	2182279-45-2
Molecular Formula	C25H32F3N3O4
Molecular Weight	495.54 g/mol
Synonyms	(+)-Silodosin; (R)-Silodosin; Silodosin R-enantiomer; KMD-3213; 1-[3-Hydroxypropyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide; KMD 3213
EINECS	Contact for details

Quality Control

Our S-Silodosin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, enantiomeric purity, and related substances. We support compliance with cGMP, FDA, and other major pharmacopoeial standards (USP/EP) for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.2%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.