Description

2-Fluoro-6-(Trifluoromethyl)Benzoic Anhydride is a specialized fluorinated aromatic anhydride building block of significant interest in advanced organic synthesis. Its value lies in its dual functionality as a reactive anhydride and the presence of fluorine atoms, which are crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine substitution can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging fluorine's ability to improve lipophilicity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with unique thermal and chemical resistance properties.
• Organic Synthesis Reagent: Acts as an efficient acylating agent for introducing the 2-fluoro-6-(trifluoromethyl)benzoyl moiety into amines, alcohols, and other nucleophiles under mild conditions.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the development of new methodologies in organofluorine chemistry.

Basic Information

Item	Details
Product Name	2-Fluoro-6-(Trifluoromethyl)Benzoic Anhydride
CAS No.	2118332-08-2
Molecular Formula	C16H6F8O3
Molecular Weight	398.21 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)benzoic acid anhydride; Bis[2-fluoro-6-(trifluoromethyl)benzoyl] ether; 2-Fluoro-α,α,α,6-tetramethylbenzoic anhydride; 2-Fluoro-6-trifluoromethylbenzoic anhydride; 2-Fluoro-α,α,α-trifluoro-o-toluic anhydride; o-(Trifluoromethyl)-2-fluorobenzoic anhydride; 2-Fluoro-6-(trifluoromethyl)benzoic acid cyclic anhydride
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-6-(Trifluoromethyl)Benzoic Anhydride adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.