Description

5-Chloro-2-Fluoro-4-Iodo-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the halogen atoms for bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing halogenated aromatic cores used in electronic materials for displays and lighting.
• Cross-Coupling Reactions: The iodine and chlorine substituents are excellent handles for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: An important substrate for studying nucleophilic aromatic substitution and other reactions involving the fluorine atom.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Iodo-Benzoic Acid Methyl Ester
CAS No.	2091744-23-7
Molecular Formula	C8H5ClFIO2
Molecular Weight	314.48 g/mol
Synonyms	Methyl 5-Chloro-2-fluoro-4-iodobenzoate; Benzoic acid, 5-chloro-2-fluoro-4-iodo-, methyl ester; 5-Chloro-2-fluoro-4-iodobenzoic acid methyl ester; 4-Iodo-5-chloro-2-fluorobenzoic acid methyl ester; Methyl 5-chloro-2-fluoro-4-iodobenzoate; 2091744-23-7; Methyl 4-iodo-5-chloro-2-fluorobenzoate
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-4-Iodo-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and should be handled under inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.