Description

Ethyl 3-(2,2,2-Trifluoro-1-Hydroxyethyl)Benzoate is a high-value fluorinated benzoate ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the strategic incorporation of both a trifluoroethanol moiety and a benzoate ester, enabling precise molecular modifications for enhanced bioactivity and material properties. This compound is essential for R&D and production teams in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with improved metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a fluorinated intermediate in the production of specialty chemicals for electronic displays and organic light-emitting diodes.
• Complex Ligand & Catalyst Development: Employed in organometallic chemistry to create sophisticated ligands for asymmetric catalysis.
• Fluorine-Containing Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer chains, improving chemical resistance and surface properties.
• Proteolysis-Targeting Chimera (PROTAC) Linker Chemistry: Utilized in the construction of bifunctional molecules for targeted protein degradation, a cutting-edge modality in drug discovery.

Basic Information

Product Name	Ethyl 3-(2,2,2-Trifluoro-1-Hydroxyethyl)Benzoate
CAS No.	2006277-57-0
Molecular Formula	C11H11F3O3
Molecular Weight	248.20 g/mol
Synonyms	3-[(2,2,2-Trifluoro-1-hydroxyethyl)]benzoic acid ethyl ester; Ethyl 3-(2,2,2-trifluoro-1-hydroxyethyl)benzoate; Benzoic acid, 3-(2,2,2-trifluoro-1-hydroxyethyl)-, ethyl ester; 1-(3-(Ethoxycarbonyl)phenyl)-2,2,2-trifluoroethanol; m-((2,2,2-Trifluoro-1-hydroxy)ethyl)benzoic acid ethyl ester; Ethyl m-(2,2,2-trifluoro-1-hydroxyethyl)benzoate; TFHEB
EINECS	Contact for details

Quality Control

Our Ethyl 3-(2,2,2-Trifluoro-1-Hydroxyethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.