Description

3-Fluoro-2-(trifluoromethyl)benzoic acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because its unique combination of fluorine and a trifluoromethyl group on the benzoic acid scaffold imparts significant electronic and steric properties, making it a critical intermediate for developing novel active compounds. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for creating new active ingredients, as well as in material science for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved weatherability.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to introduce a highly fluorinated benzoic acid moiety into complex molecules.
• Chemical Research & Development: A versatile scaffold in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	3-Fluoro-2-(trifluoromethyl)benzoic Acid
CAS No.	261951-80-8
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2-(Trifluoromethyl)-3-fluorobenzoic Acid; 3-Fluoro-2-trifluoromethylbenzoic Acid; Benzoic acid, 3-fluoro-2-(trifluoromethyl)-; α,α,α-Trifluoro-3-fluoro-o-toluic Acid; 3-Fluoro-α,α,α-trifluoro-o-toluic Acid; 2-Trifluoromethyl-3-fluorobenzoic Acid; 3-Fluoro-2-(trifluoromethyl)benzenecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-(trifluoromethyl)benzoic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.