Description

4,5-Difluoro-2-(Trifluoromethyl)Benzoic Acid is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents, imparts significant electronic and steric properties, making it a critical intermediate for developing novel compounds with enhanced performance. This product is primarily targeted at research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine motifs for improved metabolic stability, lipophilicity, and bioactivity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms contribute to weather resistance and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a carboxylic acid derivative for amide and ester formation in complex molecule assembly.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new fluorination methodologies and creating novel chemical entities.

Basic Information

Product Name	4,5-Difluoro-2-(Trifluoromethyl)Benzoic Acid
CAS No.	261945-13-5
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	2-(Trifluoromethyl)-4,5-difluorobenzoic Acid; 4,5-Difluoro-2-trifluoromethylbenzoic Acid; Benzoic acid, 4,5-difluoro-2-(trifluoromethyl)-; 4,5-Difluoro-alpha,alpha,α-trifluoro-o-toluic Acid
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assay and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the stringent requirements of our global B2B clients. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your internal specifications and research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.