Description

2-Chloro-3,6-Difluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its unique halogenated and fluorinated structure, which is essential for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and plant growth regulators, where the difluoro and chloro substituents enhance bioactivity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and thermal stability.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and conjugated systems important in material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Polymer Modification: Acts as a monomer or modifier for introducing halogenated aromatic groups into polymers to alter physical properties like refractive index or flame retardancy.

Basic Information

Product Name	2-Chloro-3,6-Difluorocinnamic Acid
CAS No.	261762-48-5
Molecular Formula	C9H5ClF2O2
Molecular Weight	218.59 g/mol
Synonyms	(2E)-3-(2-Chloro-3,6-difluorophenyl)prop-2-enoic acid; 2-Chloro-3,6-difluorocinnamic acid; trans-2-Chloro-3,6-difluorocinnamic acid; (E)-2-Chloro-3,6-difluorocinnamic acid; 3-(2-Chloro-3,6-difluorophenyl)acrylic acid; 2-Chloro-3,6-difluoro-trans-cinnamic acid; Cinnamic acid, 2-chloro-3,6-difluoro-
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,6-Difluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.