Description

Iseganan is a synthetic antimicrobial peptide mimetic developed for topical and dermatological applications. It exhibits potent, broad-spectrum activity against Gram-positive and Gram-negative bacteria—including drug-resistant strains—without inducing rapid resistance development. This makes it a high-value active pharmaceutical ingredient (API) for advanced wound care, anti-acne formulations, and infection-preventive medical devices. Formulators and contract development & manufacturing organizations (CDMOs) in the pharmaceutical, cosmeceutical, and medical device sectors rely on Iseganan CAS NO 257277-05-7 for its favorable safety profile and mechanism of action distinct from conventional antibiotics.

Application

• Topical anti-infective agents for chronic wound management (e.g., diabetic ulcers, burns)
• Active ingredient in prescription and OTC acne treatments targeting Propionibacterium acnes and Staphylococcus epidermidis
• Coating additive for biomedical devices (catheters, implants) to prevent biofilm formation
• Preservative booster in multi-dose ophthalmic and nasal formulations requiring enhanced microbial control
• Research tool in immunodermatology studies investigating host defense peptide pathways
• Component in veterinary dermatological gels and sprays for bacterial skin infections

Basic Information

Product Name	Iseganan
CAS No.	257277-05-7
Molecular Formula	C74H123N23O18
Molecular Weight	1623.9 g/mol
Synonyms	ISG-1; Iseganan acetate; N-(4-Aminobutyl)-N'-[4-(4-aminobutoxy)phenyl]urea derivative; [Lys¹⁰,Lys¹⁴]-Iseganan; Iseganan hydrochloride (common salt form); 257277-05-7; BAY 12-8036; BAY 12-8036-01; Antimicrobial peptide mimetic BAY 12-8036
EINECS	Not listed (not assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Iseganan is manufactured under cGMP-compliant conditions and conforms to relevant pharmacopoeial requirements including USP General Chapter <1088> Peptide Impurities and ICH Q5C stability guidelines. Purity assessment utilizes validated HPLC-UV and LC-MS methods; identity is confirmed by FTIR and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, maintain relative humidity below 30% during storage and handling. Avoid repeated exposure to ambient air.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (FTIR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0–102.0%
Related Substances (HPLC)	Single impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (Karl Fischer)	≤ 5.0%
Heavy Metals	≤ 10 ppm
Microbial Limits	Total aerobic count ≤ 100 CFU/g; Absence of E. coli, S. aureus, P. aeruginosa, C. albicans

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.