Description

5-(3-Trifluoromethylphenyl)-Oxazole-4-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the unique combination of the oxazole scaffold and the electron-withdrawing trifluoromethylphenyl group, which is critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D and process development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Serves as a versatile precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the oxazole ring.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLEDs and semiconductors, where the trifluoromethyl group enhances stability and electron affinity.
• Ligand & Catalyst Development: Employed as a building block for constructing complex chelating ligands in coordination chemistry and catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for bespoke synthesis projects requiring high-purity, specialized heterocyclic carboxylic acids.

Basic Information

Product Name	5-(3-Trifluoromethylphenyl)-Oxazole-4-Carboxylic Acid
CAS No.	253315-30-9
Molecular Formula	C11H6F3NO3
Molecular Weight	257.17 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]-1,3-oxazole-4-carboxylic acid; 5-(3-Trifluoromethylphenyl)-4-oxazolecarboxylic Acid; 4-Oxazolecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-; 5-(α,α,α-Trifluoro-m-tolyl)-4-oxazolecarboxylic Acid; 5-(m-Trifluoromethylphenyl)oxazole-4-carboxylic acid; 253315-30-9; Oxazole-4-carboxylic acid, 5-(3-(trifluoromethyl)phenyl)-
EINECS	Contact for details

Quality Control

Our 5-(3-Trifluoromethylphenyl)-Oxazole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.