Description

Varenicline CAS NO 249296-44-4 is a high-purity pharmaceutical active ingredient, specifically a partial agonist of the α4β2 nicotinic acetylcholine receptor. This compound is of critical importance for its targeted mechanism of action in supporting smoking cessation therapies. It is primarily required by global pharmaceutical manufacturers and advanced research institutions for the formulation of prescription medications and clinical studies.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of prescription smoking cessation aids (e.g., Chantix®, Champix®).
• Clinical Research & Development: Used in preclinical and clinical studies to investigate neuropharmacology related to nicotine dependence.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Drug Product Manufacturing: Incorporated into final dosage forms such as tablets and capsules under Good Manufacturing Practice (GMP) conditions.
• Mechanistic Studies: Utilized in academic and institutional research to study nicotinic receptor function and addiction pathways.

Basic Information

Product Name	Varenicline
CAS No.	249296-44-4
Molecular Formula	C13H13N3
Molecular Weight	211.26 g/mol
Synonyms	Varenicline; Varenicline Base; 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine; CP-526555; Chantix (Trade Name); Champix (Trade Name); 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
EINECS	Contact for details

Quality Control

Our Varenicline is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality is assured through comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. A Certificate of Analysis (COA) is provided with each batch, detailing compliance with relevant specifications. We support development and commercial projects requiring material produced under GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.