Description

2-Fluoro-5-(Trifluoromethyl)Cinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, imparts significant electronic and steric properties, making it invaluable for modulating the activity and pharmacokinetics of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the design of molecular probes and tags for studying biological processes and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Cinnamic Acid
CAS No.	247113-91-3
Molecular Formula	C₁₀H₆F₄O₂
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[2-Fluoro-5-(trifluoromethyl)phenyl]acrylic acid; 2-Fluoro-α-(trifluoromethyl)cinnamic acid; (2E)-3-[2-Fluoro-5-(trifluoromethyl)phenyl]prop-2-enoic acid; 2-Fluoro-5-trifluoromethylcinnamic acid; FTCA; 2-F-5-TFMCA
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trifluoromethyl)Cinnamic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support applications requiring regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.