Description

4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine moiety improves bioactivity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex, fluorinated biaryl structures.
• Fluorinated Polymer Modifier: Can be incorporated as a monomer or additive to enhance the chemical resistance and thermal stability of specialty polymers.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid
CAS No.	239463-90-2
Molecular Formula	C₁₀H₆F₄O₂
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[4-Fluoro-3-(trifluoromethyl)phenyl]acrylic acid; 3-(4-Fluoro-3-(trifluoromethyl)phenyl)-2-propenoic acid; trans-4-Fluoro-α-(trifluoromethyl)cinnamic acid; 4-Fluoro-α,α,α-trifluoro-m-cinnamic acid; 4-Fluoro-3-trifluoromethylcinnamic acid; FTCA; 4F3TFCA
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.