Description

2,3,5-Trifluorocinnamic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role in introducing the trifluoromethylphenyl moiety, which is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediates: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens, improving the thermal stability and electro-optical properties of display materials.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for more efficient OLED devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A versatile building block for exploring new fluorination methodologies and creating compound libraries for screening.

Basic Information

Product Name	2,3,5-Trifluorocinnamic Acid
CAS No.	237761-79-4
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,3,5-Trifluorophenyl)prop-2-enoic acid; trans-2,3,5-Trifluorocinnamic Acid; (E)-3-(2,3,5-Trifluorophenyl)acrylic acid; 2,3,5-Trifluorocinammic Acid; β-(2,3,5-Trifluorophenyl)acrylic Acid; 237761-79-4; 2,3,5-Trifluoro-trans-cinnamic Acid
EINECS	Contact for details

Quality Control

Our 2,3,5-Trifluorocinnamic Acid is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.