Description

2,3-Difluoro-4-(Trifluoromethyl)Benzoic Acid is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for creating high-performance, fluorinated polymers with enhanced chemical resistance and low surface energy.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry and material science for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2,3-Difluoro-4-(Trifluoromethyl)Benzoic Acid
CAS No.	237424-17-8
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	2,3-Difluoro-4-(trifluoromethyl)benzoic acid; Benzoic acid, 2,3-difluoro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2,3-difluorobenzoic acid; 2,3-Difluoro-alpha,alpha,α-trifluoro-p-toluic acid; 237424-17-8; 2,3-Difluoro-4-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.