Description

6-(Trifluoromethyl)Nicotinic Acid is a high-value trifluoromethyl-substituted pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, combining a nicotinic acid core with a trifluoromethyl group, imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This advanced pharmaceutical intermediate is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and receptor modulator research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological mechanisms and drug-target interactions.

Basic Information

Product Name	6-(Trifluoromethyl)Nicotinic Acid
CAS No.	231291-22-8
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-(Trifluoromethyl)pyridine-5-carboxylic acid; 5-Carboxy-2-(trifluoromethyl)pyridine; Nicotinic acid, 6-(trifluoromethyl)-; 6-Trifluoromethylnicotinic acid; 2-Trifluoromethyl-5-pyridinecarboxylic acid; 5-Pyridinecarboxylic acid, 2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.