Description

5-Fluoro-2-(trifluoromethyl)cinnamic acid is a high-value fluorinated cinnamic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is utilized to construct novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine motif for improved efficacy and environmental profile.
• Material Science Precursor: Employed in the creation of specialty polymers and liquid crystal materials that require specific electronic and steric properties.
• Chemical Biology Probe Development: Acts as a core scaffold for designing molecular probes and inhibitors used in biochemical and pharmacological research.
• Organic Synthesis Reagent: Serves as a versatile reactant in cross-coupling reactions, Michael additions, and other transformations to introduce fluorinated aromatic systems.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethyl)Cinnamic Acid
CAS No.	231291-18-2
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-[5-Fluoro-2-(trifluoromethyl)phenyl]acrylic acid; 3-(5-Fluoro-2-(trifluoromethyl)phenyl)-2-propenoic acid; 5-Fluoro-α-methyl-2-(trifluoromethyl)cinnamic acid (related); 2-Propenoic acid, 3-[5-fluoro-2-(trifluoromethyl)phenyl]-; FTCA (abbreviation); 5-Fluoro-2-trifluoromethylcinnamic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(trifluoromethyl)cinnamic acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.