Description

2,4-Difluoro-3-Methoxybenzoyl Chloride is a high-purity, multi-functional aromatic acid chloride building block. This compound is critical for introducing the 2,4-difluoro-3-methoxybenzoyl moiety into complex molecules, enabling precise structural modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in fluorinated compound libraries.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluoro-methoxy pattern confers specific biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Preparation: Employed in the creation of complex ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom chemical synthesis services targeting fluorinated aromatic targets.
• Academic & R&D Laboratories: Used in methodological studies and exploratory chemistry involving acyl chloride reactions.

Basic Information

Product Name	2,4-Difluoro-3-Methoxybenzoyl Chloride
CAS No.	221221-11-0
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	3-Methoxy-2,4-difluorobenzoyl chloride; 2,4-Difluoro-3-methoxybenzoic acid chloride; 2,4-Difluoro-m-anisoyl chloride; 2,4-Difluoro-3-methoxybenzoyl chloride; Benzoyl chloride, 2,4-difluoro-3-methoxy-; 3-Methoxy-2,4-difluorobenzoic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-3-Methoxybenzoyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.