Description

4-Hydroxy-3-(Trifluoromethyl)Benzoic Acid is a high-value trifluoromethylated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with a trifluoromethyl substituent, makes it indispensable for creating compounds with enhanced metabolic stability and lipophilicity. This intermediate is primarily sought after by pharmaceutical, agrochemical, and material science R&D teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group improves bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing monomers used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Incorporated as a functional monomer to impart special properties like hydrophobicity and chemical resistance to engineered polymers.
• Complex Ligand Synthesis: Utilized in organometallic chemistry to create specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing high-performance, light-fast fluorinated dyes and pigments.

Basic Information

Item	Detail
Product Name	4-Hydroxy-3-(Trifluoromethyl)Benzoic Acid
CAS No.	220239-68-9
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	3-(Trifluoromethyl)-4-hydroxybenzoic acid; 4-Hydroxy-3-trifluoromethylbenzoic acid; 2-Hydroxy-5-carboxybenzotrifluoride; Benzoic acid, 4-hydroxy-3-(trifluoromethyl)-; 4-Hydroxy-α,α,α-trifluoro-m-toluic acid; 3-Trifluoromethyl-4-hydroxybenzoic acid; 4-Hydroxy-3-trifluoromethyl-benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-3-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming adherence to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.