Description

Dabuzalgron CAS NO 219311-44-1 is a selective α1A-adrenoceptor agonist, a compound of significant interest in pharmacological research and development. Its primary value lies in its targeted mechanism of action, which makes it a crucial tool for studying urogenital and cardiovascular systems. This product is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on developing novel therapeutics for conditions like benign prostatic hyperplasia (BPH) and stress urinary incontinence.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in drug development and manufacturing.
• Biochemical Research: Used as a selective pharmacological probe to investigate the function and signaling pathways of α1A-adrenergic receptors in vitro and in vivo.
• Preclinical Studies: A key active pharmaceutical ingredient (API) intermediate or tool compound in animal model studies for urological disorders.
• Drug Discovery Programs: Employed in high-throughput screening (HTS) and lead optimization campaigns targeting adrenoceptors.
• Metabolite Identification: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to identify and characterize metabolic pathways.
• Analytical Method Development: Acts as a standard for developing and validating sensitive analytical methods such as HPLC, LC-MS, and GC-MS.

Basic Information

Item	Detail
Product Name	Dabuzalgron
CAS No.	219311-44-1
Molecular Formula	C19H24N2O3
Molecular Weight	328.41 g/mol
Synonyms	Ro 115-1240; (R)-(-)-5-[2-[[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole; (R)-Dabuzalgron; (R)-5-[2-[[2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole; α1A-Adrenoceptor Agonist; Selective α1A-AR Agonist
EINECS	Contact for details

Quality Control

Every batch of Dabuzalgron is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. We provide comprehensive analytical data supporting compliance with research-grade standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay purity, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.