Description

Ethyl 3,5-Difluorobenzoylformate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its value lies in its role as a versatile precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers engaged in creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials where the introduction of a difluorobenzoyl moiety is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the biological activity imparted by the difluorophenyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its aromatic and fluorinated structure.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated aromatic architectures.
• Academic and R&D Laboratories: Used in methodological development and exploratory chemistry for new C-C and C-heteroatom bond-forming reactions.

Basic Information

Product Name	Ethyl 3,5-Difluorobenzoylformate
CAS No.	208259-57-8
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Ethyl 3,5-difluoro-2-oxo-2-phenylacetate; 3,5-Difluorobenzoylformic Acid Ethyl Ester; Ethyl (3,5-Difluorophenyl)(oxo)acetate; Ethyl 2-(3,5-Difluorophenyl)-2-oxoacetate; α-Oxo-3,5-difluorobenzeneacetic Acid Ethyl Ester; 208259-57-8; Ethyl 3,5-difluorobenzoylformate
EINECS	Contact for details

Quality Control

Our Ethyl 3,5-Difluorobenzoylformate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.