Description

(3,5-Difluorophenyl)-Difluoroacetic Acid is a high-purity, multi-fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluorophenyl ring and a difluoroacetic acid moiety, makes it a versatile intermediate for introducing fluorine atoms into target molecules, a key strategy in modern pharmaceutical and agrochemical design. This compound is essential for researchers and process chemists in the life sciences sector seeking to develop new active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

The primary value of (3,5-Difluorophenyl)-Difluoroacetic Acid lies in its role as a sophisticated synthon. Its applications are centered on the research and development of novel fluorinated compounds.

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and anti-infective drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for fluorinated ligands used in asymmetric catalysis and material science.
• Fluorinated Liquid Crystal & OLED Materials: Employed in the research of electronic display components and organic light-emitting diodes due to the influence of fluorine on electronic properties.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in synthesizing fluorinated radiotracers for medical imaging.
• Custom Synthesis & Contract Research: A valuable starting material for custom fluorination projects and research-scale compound libraries in CROs (Contract Research Organizations).

Basic Information

Item	Detail
Product Name	(3,5-Difluorophenyl)-Difluoroacetic Acid
CAS No.	208259-48-7
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,2-Difluoro-2-(3,5-difluorophenyl)acetic Acid; α,α-Difluoro-3,5-difluorophenylacetic Acid; 3,5-Difluorophenyl(difluoro)acetic Acid; (3,5-Difluorophenyl)difluoroethanoic Acid; Difluoro(3,5-difluorophenyl)acetic Acid; NSC 405124; 208259-48-7 (CAS)
EINECS	Contact for details

Quality Control

Our production of (3,5-Difluorophenyl)-Difluoroacetic Acid adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for traceability and reliability, making this material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.