Description

2-Fluoro-3-(trifluoromethyl)benzoyl chloride is a high-value fluorinated aromatic acid chloride building block essential for advanced organic synthesis. Its core value lies in introducing both fluorine and a reactive acyl chloride group into target molecules, enabling the rapid construction of complex amides and esters. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Liquid Crystal Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystal compounds used in display technologies.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic acyl substitution reactions to form amides, esters, and ketones under mild conditions.
• Chemical Research & Development: Fundamental material for method development and exploring new chemical entities in academic and industrial R&D laboratories.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)benzoyl Chloride
CAS No.	208173-19-7
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	2-Fluoro-3-(trifluoromethyl)benzoyl chloride; 3-Trifluoromethyl-2-fluorobenzoyl chloride; 2-Fluoro-alpha,alpha,α-trifluoro-m-toluoyl chloride; Benzoyl chloride, 2-fluoro-3-(trifluoromethyl)-; 208173-19-7; 2-Fluoro-3-trifluoromethylbenzoyl chloride; m-Trifluoromethyl-o-fluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)benzoyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.