Description

2-Fluoro-4-(Trifluoromethyl)Benzamide is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a specific trifluoromethyl-substituted benzamide scaffold into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance efficacy and environmental stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique electronic properties.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag in biochemical research due to its distinct spectroscopic signature.
• Organic Synthesis: A versatile reagent for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to create complex biaryl structures.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethyl)Benzamide
CAS No.	207853-64-3
Molecular Formula	C8H5F4NO
Molecular Weight	207.13 g/mol
Synonyms	2-Fluoro-4-(trifluoromethyl)benzamide; Benzamide, 2-fluoro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-fluorobenzamide; 2-Fluoro-alpha,alpha,α-trifluoro-p-toluamide; 2-Fluoro-4-trifluoromethylbenzamide; 207853-64-3; AKOS BRN-0711; FT-0658081
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.