Description

2-Carboxymethyl-5-Trifluoromethyl-Benzoic Acid is a high-value, multifunctional aromatic carboxylic acid derivative, distinguished by its trifluoromethyl and carboxymethyl substituents. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex molecules with enhanced biological activity and metabolic stability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group improves lipophilicity and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing modern herbicides, fungicides, and insecticides, leveraging the stability and activity imparted by the fluorine atoms.
• Ligand and Catalyst Development: Used in organometallic chemistry and catalysis research to create novel chelating ligands for metal complexes.
• Material Science Monomer: Can be polymerized or incorporated into polymers to create specialty materials with specific chemical resistance or surface properties.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for constructing complex molecular architectures, including heterocycles and dendritic structures.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) and the effects of fluorination in organic molecules.

Basic Information

Product Name	2-Carboxymethyl-5-Trifluoromethyl-Benzoic Acid
CAS No.	207804-91-9
Molecular Formula	C10H7F3O4
Molecular Weight	248.16 g/mol
Synonyms	5-(Trifluoromethyl)phthalide-3-carboxylic Acid; 3-Carboxy-5-(trifluoromethyl)phthalide; 2-(Carboxymethyl)-5-(trifluoromethyl)benzoic Acid; 1,3-Dihydro-3-oxo-5-(trifluoromethyl)-1-isobenzofurancarboxylic Acid; 5-Trifluoromethyl-3-carboxyphthalide; 3-Carboxy-5-trifluoromethylphthalide; 2-Carboxymethyl-α,α,α-trifluoro-m-toluic Acid
EINECS	Contact for details

Quality Control

We maintain a strict quality management system aligned with cGMP principles for pharmaceutical intermediates. Every batch of 2-Carboxymethyl-5-Trifluoromethyl-Benzoic Acid undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate engineering controls.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.