Description

Methyl 2-Fluoro-4-Iodobenzoate is a high-purity, multi-functional aromatic ester building block designed for advanced chemical synthesis. This compound is valued for its unique halogenated structure, which provides distinct reactivity for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries to introduce fluorine and iodine substituents into target scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating halogenated aromatic cores in electronic and photonic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Stille couplings for carbon-carbon bond formation.
• Fluorine Chemistry Studies: Employed as a model compound in methodological development for introducing fluorine into complex organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated benzoate derivatives.

Basic Information

Product Name	Methyl 2-Fluoro-4-Iodobenzoate
CAS No.	204257-72-7
Molecular Formula	C8H6FIO2
Molecular Weight	280.04 g/mol
Synonyms	2-Fluoro-4-iodobenzoic acid methyl ester; Methyl 2-fluoro-4-iodobenzoate; Benzoic acid, 2-fluoro-4-iodo-, methyl ester; 4-Iodo-2-fluorobenzoic acid methyl ester; Methyl 4-iodo-2-fluorobenzoate; 2-Fluoro-4-iodo-benzoic acid methyl ester; Methyl ester of 2-fluoro-4-iodobenzoic acid
EINECS	Contact for details

Quality Control

Our Methyl 2-Fluoro-4-Iodobenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.