Description

5-Iodo-2,3,4-Trifluorobenzoic acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorine and iodine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Studies: Employed in academic and industrial research to study the effects of polyfluorination on aromatic system reactivity and physicochemical properties.
• Radiolabeling Precursor: The iodine atom provides a potential site for radioiodination (e.g., with I-125) for use in diagnostic imaging or tracer studies.

Basic Information

Product Name	5-Iodo-2,3,4-Trifluorobenzoic Acid
CAS No.	203916-59-0
Molecular Formula	C7H2F3IO2
Molecular Weight	293.99 g/mol
Synonyms	2,3,4-Trifluoro-5-iodobenzoic Acid; Benzoic acid, 5-iodo-2,3,4-trifluoro-; 5-Iodo-2,3,4-trifluorobenzoicacid; 203916-59-0; 2,3,4-Trifluoro-5-iodobenzoicacid
EINECS	Contact for details

Quality Control

Our 5-Iodo-2,3,4-Trifluorobenzoic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.